Kaley Cuoco almost missed out on her role in The Big Bang Theory, which could have significantly changed her career trajectory. The show may not have been as successful without her, and she may not have become as wealthy and famous as she is today. Cuoco's audition for the role of Penny initially didn't go well because she didn't fit the original vision of the character. However, the show's creators decided to retool the pilot, which led to changes in the female lead character and allowed Cuoco to fit the role perfectly.

Interestingly, before Cuoco was cast, several other famous actors were considered for the role.

Marisa Tomei, Tara Reid, and Elizabeth Berkley all auditioned but were not ultimately chosen. Jodi Lyn O'Keefe and Amanda Walsh were hired to play the female lead before Cuoco but were later fired.

Cuoco's association with The Big Bang Theory is still strong, even after the show ended. Many fans believe that she has disappeared from the spotlight, but in reality, Cuoco has continued to have a successful career in projects like Harley Quinn and The Flight Attendant.

In the end, Cuoco's rejection turned out to be a blessing in disguise, as it allowed her to secure a role that became a major milestone in her career.