The Matthew Perry Foundation has been launched with the goal of addressing addiction as a disease, combatting the stigmas associated with seeking treatment, and advocating for better and more equitable care. The late actor's family hopes that the foundation will help others suffering from addiction. Perry's stepfather, journalist Keith Morrison, has encouraged fans to donate to the foundation. Perry had planned to establish a foundation to support those struggling with substance abuse before his death. His loved ones brought this goal to fruition after his passing. Perry was open about his own battle with addiction, including his abuse of alcohol and Vicodin.

He almost died at 49 due to his escalating drug addiction. Perry was laid to rest on November 3. The cause of his death is currently listed as "deferred" pending further investigation. His family expressed their heartbreak and appreciation for the love and support they received. The foundation's website features a photo of Perry and a quote from him expressing his desire to help others and defeat addiction.