Mayim Bialik and Melissa Rauch formed a special bond while working together on the hit sitcom The Big Bang Theory. Although Bialik had friendships with other cast members, she felt closest to Rauch. They joined the show in Season 3 and grew close over the years. After the show ended, Bialik acknowledged that maintaining their tight-knit friendship was challenging without the show's set. Fans of the show continue to cherish any moments when the cast reunites or mentions each other in their ongoing careers.