The cast of The Big Bang Theory had a difficult time coming to terms with the show's end. Kaley Cuoco and Mayim Bialik both struggled with the realization, but dealt with it in their own ways. Bialik experienced various forms of grief, and the show's conclusion was a new kind of grief for her. However, she was determined to give her all during the final season and approached her character as if it were the first time playing her. Despite her emotional state, Bialik played a supportive role during the final table read, particularly comforting Cuoco.

During the table read, fans noticed Bialik consoling Cuoco, who was particularly emotional about the decision to end the show.

Cuoco had not anticipated the series ending during its twelfth season, making it even harder for her. However, she ultimately accepted the decision and was content with Penny's send-off. She described it as beautiful and felt that the characters would live on in the minds and hearts of the audience.

While Cuoco found closure in Penny's ending, Johnny Galecki, who played Leonard, initially had some confusion about the resolution. The show had previously suggested that Leonard and Penny would not have children, but in the finale, they honored the pilot episode's statement that Leonard would have Penny's children one day.

Despite the inconsistency, Galecki eventually came around and accepted the resolution, understanding that it meant Penny and Leonard would be okay.

Overall, the cast went through a range of emotions as they approached the end of The Big Bang Theory. While there were challenges and moments of sadness, they ultimately found satisfaction in the way the show concluded, and the fans appreciated the emotional support shown between Bialik and Cuoco during the final table read.