The CBS sitcoms "Young Sheldon" and "The Big Bang Theory" depict a strained relationship between Mary and Missy Cooper. In "The Big Bang Theory," Missy's life appears to be in shambles, with an impending divorce from her husband. The show suggests that Mary's denial and tendency to ignore red flags may have contributed to Missy's situation. In "Young Sheldon," Mary is shown to underestimate Missy, while Missy antagonizes her mother. Despite the Cooper family tragedy, it's uncertain if it will bring Mary and Missy closer. However, according to adult Sheldon's narration, Missy eventually lives a happy life with more children, but no mention of her love life.