In chapter #1112 of One Piece, Luffy faces off against the Five Elders, who prove to be formidable foes even with Gear Five. The chapter hints that they may be even stronger than Kaido, the strongest creature in the world. Despite their elderly appearance, the Elders display powerful Haki and durability, with Luffy unable to harm them while sustaining injuries himself. Luffy attempts to use his Gum-Gum Red Roc attack that previously injured Kaido, but the Elders remain unfazed. This marks the first time the Elders have been able to harm Luffy effortlessly. The Elders' resilience and strength in their transformed states suggest they may surpass Kaido in power. As Luffy struggles against them, it becomes clear that the Elders may be his toughest opponents yet, setting them up as the ultimate antagonists of the series. One Piece fans can read the latest chapters on Manga Plus and Viz Media.