He became a household name for his long-running turn as charismatic lawman Tony DiNozzo Jr.
But NCIS star Michael Weatherly revealed on Tuesday he leaving the popular role after 13 years on the hit CBS show.
It comes after the 47-year-old was charged on two counts of DUI after he was allegedly caught speeding in Hollywood last November.
'It's been a fantastic ride': Michael Weatherly revealed his 13 year stint on NCIS was at an end on Tuesday just months after an early morning DUI speeding arrest
The 47-year-old said on Twitter: 'DiNozzo is a wonderful, quixotic character and I couldn't have had more fun playing him over the past 13 seasons.
'(CBS president) Les Moonves and CBS gave me the opportunity of a lifetime.
'I will miss the amazing crew and cast, who are like family to me, and to the fans all over the world — THANK YOU, it's been a fantastic ride!'
The station also confirmed he would end his stint on the police procedural show, which follows a team of special agents from the Naval Criminal Investigative Service, at the end of the current season.
Bittersweet: The star paid tribute to the cast, crew and CBS in a series of emotional tweets
Onscreen: Michael starring as Special Agent Anthony DiNozzo on NCIS alongside Cote de Pablo
A spokesman added: 'He is a valued part of the CBS family, and the immense charm and talent he brings to the screen as "Very" Special Agent Tony DiNozzo has helped make NCIS what it is today – the No. 1 drama in the world.'
CBS also said it hopes to pursue future projects with the actor in the future.
It comes after Weatherly, ex-fiancé of Jessica Alba, got charged with two counts of DUI after spending spent 15 hours behind bars after he was allegedly caught speeding in November..