In an article about the hit show "The Big Bang Theory," the writer discusses memorable unscripted moments that occurred during the show's 12-season run. One such moment involved Jim Parsons stumbling over a line during Sheldon's Nobel Prize speech. The article also mentions that the show's writers were skilled at rewriting jokes on the spot if they didn't land. Additionally, it highlights the emotional challenges the cast faced during the final episodes, with Kaley Cuoco being shocked by Parsons' decision to leave and genuine tears being shed during Sheldon's speech.